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OMER KOC UNIVERSITY HOSPITALS OF CLEVELAND PDF
The Crossmark icon will be present on pdf and HTML versions of the article. Journal of Plant Science and Phytopathology understands the significance of the integrity and completeness of the scholarly record and attaches the highest importance to maintaining trust in the authority of its electronic archive. Journal of Plant Science and Phytopathology maintains the Crossmark icon with a commitment to maintain the updated published content and alert readers whenever any change occurs in the published content. Thus, ΔMGMT-transduced murine bone marrow cells selectively survive in vivo BG and BCNU exposure, resulting in prolonged enrichment for the transduced cells and protection from mortality induced by this drug combination.Crossmark is a unique initiative from CrossRef to facilitate a standard way for readers to locate the authoritative version of a document. Furthermore, whereas 21 of 22 mice transplanted with ΔMGMT-transduced cells survived in vivo BG and BCNU administration, only 3 of 13 mice transplanted with lacZ-transduced progenitors survived similar drug treatment. The degree of drug resistance in ΔMGMT-transduced hematopoietic progenitors to BG and BCNU was much greater than we observed previously with wild-type MGMT gene transfer and treatment with BCNU alone. CFU-C obtained from BG and BCNU-treated ΔMGMT animals up to 23 weeks after transplantation were more resistant to combination BG and BCNU than CFU-C from mice transplanted with lacZ-transduced cells and treated with BG and BCNU or from mice transplanted with ΔMGMT-transduced cells and left untreated. Learn more about Omer Koc, Ireland Cancer Ctr, a(n) Oncologist in Cleveland, OH. After one cycle of BG and BCNU, ΔAGT expression was observed in 60% of bone marrow cells, and the percentage of colony-forming units (culture CFU-C) containing proviral sequence increased from 67 to 100%. Learn more about MA Patrick MD - University Hospitals of Cleveland. Transplantation of ΔMGMT-transduced cells resulted in δAGT expression in 30% of bone marrow nucleated cells 13 weeks after transplantation. Following transplantation into lethally irradiated mice, the transduced cells were subjected to in vivo BG and BCNU treatment to examine the ability to enrich for transduced cells expressing ΔAGT. The retroviral vector MFG was used to transfer the G156A MGMT (ΔMGMT) cDNA, encoding a mutant AGT that is resistant to inhibition by BG, into murine bone marrow-derived hematopoietic progenitors. A retroviral gene therapy approach was developed to protect early hematopoietic progenitors from 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a stem cell toxin, and O 6-benzylguanine (BG), an inhibitor of a key BCNU resistance protein, O 6-alkylguanine DNA alkyltransferase (AGT).
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